MOTS-c Calculator
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA mitochondrial gene. Animal studies report effects on metabolism, insulin sensitivity, and exercise capacity.
| 5 mg | lyophilized powder |
| 10 mg | lyophilized powder |
| 2 mg | ≈ 40 U-100 units (at 10mg / 2mL) |
| 5 mg | ≈ 100 U-100 units (at 10mg / 2mL) |
| 10 mg | ≈ 200 U-100 units (at 10mg / 2mL) |
How it's typically prepared
Reconstitute with BAC water; refrigerate.
MOTS-c Dosage
MOTS-c dosage protocols in research-peptide practice typically use 5–10 mg per dose, given subcutaneously two to three times per week. The dose range derives from preclinical animal studies and early human pilot work — no large randomized trial has established a clinically approved MOTS-c dose.
At the standard research-vendor reconstitution of 10 mg / 2 mL (5 mg/mL concentration), a 5 mg dose draws to 100 units on a U-100 insulin syringe — the full length of a standard 1 mL insulin syringe. A 2 mg starter dose draws to 40 units. The volume per dose at 5 mg/mL means a single 10 mg vial provides one or two doses depending on protocol.
MOTS-c is a mitochondrial-derived peptide — encoded within the 12S rRNA gene rather than nuclear DNA — and signals between mitochondria and the nucleus. Reported preclinical effects include improvements in insulin sensitivity and exercise capacity, with most research-peptide protocols cycling for 8 to 12 weeks before reassessment.
MOTS-c Dosage Chart
U-100 insulin syringe units for common MOTS-c doses at the standard 10 mg / 2 mL reconstitution (5 mg/mL).
| 2 mg | 40 units · 0.40 mL |
| 5 mg | 100 units · 1.00 mL |
| 10 mg | 200 units · 2.00 mL (full vial) |
Frequently asked questions
- What is MOTS-c?
- A peptide encoded by mitochondrial DNA that signals between mitochondria and the nucleus, with metabolic effects in animal models.
Where researchers source this
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PeptideDose is an educational reference. It is not medical advice and does not replace consultation with a licensed healthcare provider. Doses shown in presets are derived from published protocols and product labels — they are not personal recommendations.