How many units is 0.25 mg of semaglutide?

On a U-100 insulin syringe, 0.25 mg of semaglutide equals 10 units when the vial is reconstituted at 5 mg / 2 mL (2.5 mg/mL).

How many units is 0.5 mg of semaglutide?

At 5 mg / 2 mL concentration, 0.5 mg equals 20 units on a U-100 insulin syringe.

What's the typical titration schedule?

0.25 mg weekly for 4 weeks → 0.5 mg for 4 weeks → 1 mg for 4 weeks → 1.7 mg for 4 weeks → 2.4 mg maintenance. Always defer to your provider's specific schedule.

Can I split a weekly dose into two smaller doses?

Some clinicians split the weekly dose to reduce GI side effects. This is a clinical decision and should be made with your provider — the calculator will compute either the full or split volume.

Semaglutide Calculator

Also known as: Ozempic, Wegovy, Rybelsus

GLP-1

Default: 5mg / 2mL / 0.25mgAdjust inputs to match your vial

About

What is Semaglutide?

Semaglutide is a once-weekly GLP-1 receptor agonist developed by Novo Nordisk and approved as Ozempic for type 2 diabetes, Wegovy for chronic weight management, and Rybelsus as an oral tablet. Subcutaneous protocols start at 0.25 mg weekly for four weeks and titrate every four weeks (0.5 → 1 → 1.7 → 2.4 mg) to a maintenance dose. Compounded semaglutide ships as a lyophilized powder in 2 mg through 15 mg vials. At 5 mg / 2 mL the concentration is 2.5 mg/mL — a 0.25 mg starter dose draws to 10 units on a U-100 insulin syringe.

Common vial sizes

2 mg	lyophilized powder
3 mg	lyophilized powder
5 mg	lyophilized powder
10 mg	lyophilized powder
15 mg	lyophilized powder

Reference dose ranges

0.25 mg	≈ 10 U-100 units (at 5mg / 2mL)
0.5 mg	≈ 20 U-100 units (at 5mg / 2mL)
1 mg	≈ 40 U-100 units (at 5mg / 2mL)
1.7 mg	≈ 68 U-100 units (at 5mg / 2mL)
2 mg	≈ 80 U-100 units (at 5mg / 2mL)
2.4 mg	≈ 96 U-100 units (at 5mg / 2mL)

Reconstitution

How it's typically prepared

Inject BAC water against the inner wall of the vial and swirl gently to dissolve. Refrigerated solutions are typically considered viable for 28–56 days depending on the compounding pharmacy.

FAQ

Frequently asked questions

How many units is 0.25 mg of semaglutide?: On a U-100 insulin syringe, 0.25 mg of semaglutide equals 10 units when the vial is reconstituted at 5 mg / 2 mL (2.5 mg/mL).
How many units is 0.5 mg of semaglutide?: At 5 mg / 2 mL concentration, 0.5 mg equals 20 units on a U-100 insulin syringe.
What's the typical titration schedule?: 0.25 mg weekly for 4 weeks → 0.5 mg for 4 weeks → 1 mg for 4 weeks → 1.7 mg for 4 weeks → 2.4 mg maintenance. Always defer to your provider's specific schedule.
Can I split a weekly dose into two smaller doses?: Some clinicians split the weekly dose to reduce GI side effects. This is a clinical decision and should be made with your provider — the calculator will compute either the full or split volume.

Sources

References

Other GLP-1 peptides

Notice

PeptideDose is an educational reference. It is not medical advice and does not replace consultation with a licensed healthcare provider. Doses shown in presets are derived from published protocols and product labels — they are not personal recommendations.